DNA, its composition, and the speculations never seize to amaze people. After the discovery of the DNA as a double helix in the year 1950 by Watson and Crick a lot of theories got evolved about the existence of human being and their nature. Some of the biological mysteries about the human beings about giving birth also got revealed, and this leads to what we call as modern genetics today. The DNA and its theories did not stop only here. Scientists are still investigating the unknown facts related to it and solving the complexities related to it.
As per a new study, a new shape of DNA present in the human cells has been discovered. The study is published in Nature Chemistry by a team of scientists and researchers from the Kinghorn Centre for Clinical Genomics at the Garvan Institute of Medical Research in Sydney. They have described the DNA as a four-stranded knot-like structure known as i-motif. It is present in human cells and comprises a lot of details which is still a matter of study. The role of this structure needs to be investigated in the new research to solve many more theories related to DNA.
Scientists told that DNA is also found in triple helices or cruciforms and the discovery of i-motif in its four stranded networks is something unusual. Earlier these i-motifs were never found in the human genome cells, however, two decades ago they were observed in the acidic lab conditions. It was supposed by the researchers that these i-motifs would never be found in nature, but the new study has confirmed its presence.
This whole study has raised a debate among the scientists about the existence of i-motifs naturally in the human genome. The researchers had to provide the direct evidence of their existence in the cells under the physiological conditions. To confirm their presence the team of scientists from Sydney made a particular fragment of an antibody molecule. This antibody can bind to these i-motif structures.
Later with the help of fluorescent techniques, the antibody molecules were observed under the microscope. The function of i-motif is still under investigation and scientists are working on this aspect as well. The team of scientists and researchers has found that motifs arise when DNA is being transcribed. However later they disappear when DNA is replicated.